The specialist journal Blood of the American Association of Hematology published on Thursday, the results of a team of French researchers that could revolutionize the field of blood transfusions. Researchers at the Joint Research Unit Inserm-UPMC and the AP-HP are indeed able to perform the first autologous human red blood cells from stem cells.
Ultimately, this breakthrough could enable medical transfused to become their own donors, enough to solve the problems with blood supply and reduce risk of infection during transfusions. After conducting tests on mice, the team led by Luc Douay led his experience a volunteer donor. The researchers then injected into the body of the patient red blood cells grown (RCMP) from its own stem cells. They then observed their survival in the bloodstream. With 94% to 100% survival rate after five days, then 41 to 63% after 26 days, "the life and survival of cultured cells are similar to those of red blood cells' classic ", note the Inserm in a statement. "This supports their validity as possible source of transfusion, "concluded the Institute.
To complete the experience, the team has Douay Pr Product Laboratory billion RcMP from human hematopoietic stem cells (HSC), the cells that produce all types of blood cells. They also resorted to growth factors that help regulate the proliferation and maturation of these cells. The road to open so blood autotransfusion, but has yet to benefit from progress, particularly in regard to large-scale production of CSH. So that future transfusions are no longer dependent on generous donors but often in short supply.
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