He studied how genes in the immune system and bile turnover may contribute to severe bile duct disease.
New treatment next
According to Hov talks thesis that disturbances in the immune system and bile acid regulation contributes to primary sclerosing rendering cholangitt (PSC). He believes that the work provides several clues for further studies.
- Increased understanding of disease mechanisms are in turn essential to develop new treatments, he said in a statement.
Source of pic : http://www.niaid.nih.gov/topics/immuneSystem/Pages/structureImages.aspx
Source of pic : http://staroversky.com/psychology/stress-simple-visual-summary/attachment/immune-system-response-to-stress/
Source of pic : http://cancerhq.org/2010/10/05/top-5-immune-system-boosters/
Through the thesis work examined the Hov in detail parts of the genetic material, where previous studies have shown that there are variants that predispose to PSC.
Receptor possible contributor
In a study of a genomic area on chromosome 2 points Hov and his colleagues in the gene for bile acid receptor TGR5 as a possible contributor to the PSC.
- TGR5 affect Gallen composition and activity of certain inflammatory cells. We identified a number of new varieties of TGR5 gene. It turned out to change TGR5 its structure or function, he points out.
The researchers also studied the HLA region on chromosome 6 They point to two other mechanisms that may contribute to the PSC. In one study it was found that the gene variants that contribute to increased activity in a type of white blood cells (NK cells) had higher prevalence of PSC.
- This suggests that they may be involved in the disease process, says Hov.
Disposition of immune responses
In another study, researchers found that HLA-DR molecule has specific characteristics of the PSC, which may help the patients are predisposed to immune responses against specific proteins.
- Such immune responses are central to the so-called autoimmune diseases. It might explain why the PSC framework right bile duct, maintains Hov on the occasion of the defense.
